BC 1995 - breast cancer - analysis details: endpoints, steering files and strata

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Contents List

BC 1995 - breast cancer

BC 1995 run-time diktats
List of BC 1995 endpoints
BC 1995 endpoint definitions (awaiting re-write)
List of BC 1995 strata

Data structure and protocols for BC 1995

BC 1995 run-time diktats

Run-time estimation of unknown randomisation date

Set randomisation date to the earliest known date of:

Today
Cutoff date (if any)
LFU/death date
Distant recurrence date
Recurrence date
Second primary breast cancer date

Run-time estimation of unknown endpoint/censoring date

Set endpoint/censoring date to the latest known date of:

Randomisation date
Second primary breast cancer date
Recurrence date
Distant recurrence date

Run-time application of cut-off date, where relevant

If the randomisation date is later than the cut-off date, omit the case.
If the endpoint/censoring date is after the cut-off date, censor at the cut-off date instead.

Run-time estimation of unknown menopausal status

Entry age < 50: Premenopausal
Entry age 50+: Postmenopausal
Entry age unknown: Perimenopausal

Run-time estimation of unknown entry age (except for the detailed-age-stratified analyses)

Premenopausal: 40
Perimenopausal: 50
Other/unknown: 60

Run-time definition of 'probable breast cancer deaths'

Includes all deaths with recurrence or contralateral second primary, and those with 'unknown cause'

List of BC 1995 endpoints

	Endpoint	Mnemonic	Trial inclusion criteria
1	MORTALITY	DD
2	RECURRENCE-FREE SURVIVAL	RL	recurrence
3	BREAST CANCER MORTALITY (not used)	DDBC
4	DISTANT RECURRENCE	DIST	recurrence, site
5	MORTALITY FROM SECOND PRIMARY CANCER	DDPP	death cause
6	MORTALITY FROM UNKNOWN CAUSES WITHOUT RECORDED RECURRENCE	DDUKRL
7	MORTALITY FROM OTHER AND UNSPECIFIED NON-BREAST-CANCER CAUSES	NONBCUS	death cause
8	CARDIAC MORTALITY	HEART	death cause
9	MORTALITY FROM NON-BREAST-CANCER, NON-VASCULAR CAUSES	NONBCVASC	death cause
10	MORTALITY FROM LYMPHATIC AND HAEMATOPOIETIC CAUSES	DDLEUK	death cause
11	ENDOMETRIAL CANCER MORTALITY	DDENDO	death cause
12	MORTALITY FROM KNOWN NON-BREAST-CANCER CAUSES WITHOUT RECURRENCE	NONBC	death cause
13	VASCULAR MORTALITY	VASC	death cause
14	CONTRALATERAL BREAST CANCER AS FIRST EVENT	CONT	contralateral
15	ISOLATED LOCAL RECURRENCE AS FIRST EVENT	RLLI	recurrence, site
16	DISTANT RECURRENCE AS FIRST EVENT	RLD	recurrence, site
17	RECURRENCE AS FIRST EVENT	RLF	recurrence
18	MORTALITY OMITTING DEATHS FROM NON-BREAST-CANCER CAUSES WITHOUT RECURRENCE = (DD - NONBC)	DDPOSTREC
19	RECURRENCE AT UNKNOWN SITE AS FIRST EVENT	RLU	recurrence
20	RECURRENCE AS FIRST EVENT OMITTING ISOLATED LOCAL RECURRENCES AS FIRST EVENT = (RLF - RLLI)	RLNL	recurrence, site
21	MORTALITY AFTER ISOLATED LOCAL RECURRENCE AS FIRST EVENT	DDLI	recurrence, site
22	COLORECTAL CANCER MORTALITY	DDCOLO	death cause
23	ENDOMETRIAL CANCER INCIDENCE	ENDO	second malignancy
24	COLORECTAL CANCER INCIDENCE	COLO	second malignancy
25	SECOND PRIMARY CANCER INCIDENCE	PP	second malignancy
26	NON-CONTRALATERAL RECURRENCE AS FIRST EVENT	RLFNC	recurrence
27	RECURRENCE AS FIRST EVENT OMITTING NON-CONTRALATERAL = (RLF - RLFNC)	RLCONT	recurrence, contralateral
28	CEREBROVASCULAR MORTALITY	CEREB	death cause
29	OVARIAN CANCER MORTALITY	DDOVAR	death cause
30	THROMBOTIC AND EMBOLIC MORTALITY	DDTHEMB	death cause
31	PULMONARY EMBOLISM MORTALITY	DDPE	death cause
32	MORTALITY FROM EXTRANEOUS CAUSES	EXTRA	death cause
33	MORTALITY FROM KNOWN-SITE NON-ENDOMETRIAL SECOND PRIMARY CANCER	DDPPNE	death cause
34	MORTALITY FROM UNKNOWN-SITE CANCER	DDPPU	death cause
35	MORTALITY FROM IATROGENIC CAUSES	IATRO	death cause
36	PNEUMONIA MORTALITY	PNEUM	death cause
37	MORTALITY FROM UNSTATED CAUSES	DC0
38	MORTALITY FROM OTHER SPECIFIED CAUSES	DC9	death cause
39	MORTALITY FROM UNSPECIFIED NON-BREAST-CANCER CAUSES	DC10	death cause
40	MORTALITY FROM UNASCERTAINABLE CAUSES	DC12	death cause
41	MORTALITY FROM NON-PNEUMONIA RESPIRATORY CAUSES	DDRESP	death cause
42	MORTALITY FROM HEPATIC CAUSES	DDHEP	death cause
43	MORTALITY FROM NON-PNEUMONIA INFECTIVE CAUSES	INFECTNP	death cause
44	MORTALITY FROM OTHER VASCULAR CAUSES	OVASC	death cause
45	OVARIAN CANCER INCIDENCE	OVAR	second malignancy
46	HEPATIC CANCER INCIDENCE	HEP	second malignancy
47	MORTALITY FROM HEPATIC CANCER	DDHEPC	death cause
48	MORTALITY FROM KNOWN NON-BREAST-CANCER CAUSES WITHOUT RECURRENCE, EXCLUDING ENDOMETRIAL CANCER	NONBCENDO	death cause
49	SECOND PRIMARY CANCER INCIDENCE AT KNOWN SITE	PPK	second malignancy
50	SECOND PRIMARY CANCER INCIDENCE AT UNKNOWN SITE	PPUK	second malignancy
51	LUNG CANCER INCIDENCE	LUNG	second malignancy
52	LEUKAEMIA AND LYMPHOMA INCIDENCE	LEUK	second malignancy
53	MORTALITY FROM NON-BREAST-CANCER AND UNKNOWN CAUSES WITHOUT RECURRENCE	NONBCUK
54	MORTALITY OMITTING DEATHS FROM NON-BREAST-CANCER AND UNKNOWN CAUSES WITHOUT RECURRENCE = (DD - NONBCUK)	DDPOSTRECB
55	MORTALITY OMITTING DEATHS FROM NON-BREAST-CANCER CAUSES (EXCLUDING ENDOMETRIAL CANCER) WITHOUT RECURRENCE = (DD - NONBCENDO)	DDPOSTRECC
56	SURVIVAL AFTER RECURRENCE	DDRL	recurrence

BC 1995 endpoint definitions (should be read in conjunction with Diktats)

PLEASE NOTE THAT THIS ENTIRE SECTION IS OUT OF DATE AND IS AWAITING A COMPLETE RE-WRITE!!!

Run-time strategy for data errors

Although efforts are made to create and maintain an 'error-free' database, numerous minor logical inconsistencies may persist during correspondence with trialists. In addition to the Diktats concerning missing dates etc, the following precepts are applied globally at run-time:

In addition to cases with 'first recurrence' flags set, a first recurrence is taken to be present if a date of first recurrence is present.
In addition to cases with 'first distant recurrence' flags set, both a first recurrence and a first distant recurrence are taken to be present if a date of first distant recurrence is present.
If dates of first recurrence and first distant recurrence both exist, the date of first recurrence is taken as the earlier of the two. Alternatively, if only the date of first distant recurrence exists and the 'first recurrence' flag is set to 'no', the date of first recurrence is set to the date of first distant recurrence.
In addition to cases with 'contralateral breast cancer' flags set, contralateral breast cancer is taken to be present if a date of contralateral breast cancer exists, except that if reported on (or before) the randomisation date (if non-null) it is disregarded throughout (with the exception of the 'CONT' endpoint, for which such cases are censored at the randomisation date).

CONT: CONTRALATERAL BREAST CANCER AS FIRST EVENT

An event is taken to have occurred if:

contralateral breast cancer is reported; and

the date of contralateral breast cancer does not exist and a recurrence is not reported; or
the date of contralateral breast cancer exists; and

a date of first recurrence does not exist or the date of first recurrence is on or later than the date of contralateral breast cancer; and
a date of first distant recurrence does not exist or the date of first distant recurrence is on or later than the date of contralateral breast cancer.

The event date is taken as the date of contralateral breast cancer.

If an event is not taken to have occurred, the case is censored at the randomisation date if the date of contralateral breast cancer is on or before the randomisation date, or else at THE EARLIEST OF the date died or last traced, the date of first recurrence (if non-null) and the date of first distant recurrence (if non-null).

DD: MORTALITY

An event is taken to have occurred if:

death has occurred.

The event date is taken as the date died.

If an event is not taken to have occurred, the case is censored at the date last traced.

DDBC: BREAST CANCER MORTALITY

SYSTEMIC THERAPY OVERVIEW VERSION:

An event is taken to have occurred if:

death has occurred; and

the cause of death is 'breast cancer', 'unknown' or is not stated; or
a recurrence is reported; or
contralateral breast cancer is reported.

The event date is taken as the date died.

If an event is not taken to have occurred, the case is censored at the date last traced.

LOCAL THERAPY OVERVIEW VERSION:

An event is taken to have occurred if:

death has occurred; and

the cause of death is 'breast cancer'; or
a distant recurrence is reported; or
contralateral breast cancer is reported; or
the cause of death is 'unknown' or is not stated; and

the trial/stratum lacks recurrence data; or
the trial/stratum does not lack recurrence data and the trial/stratum lacks recurrence site data and a recurrence is reported.

The event date is taken as the date died.

If an event is not taken to have occurred, the case is censored at the date last traced.

DDPOSTREC: MORTALITY OMITTING DEATHS FROM NON-BREAST-CANCER CAUSES WITHOUT RECURRENCE

This endpoint is formed by subtraction of the annual events, (O - E) and variance of NONBC from DD, q.v.

DDUKRL: MORTALITY FROM UNKNOWN CAUSES WITHOUT RECORDED RECURRENCE

An event is taken to have occurred if:

death has occurred; and
the cause of death is 'unknown' or is not stated; and
a recurrence is not reported; and
contralateral breast cancer is not reported.

The event date is taken as the date died.

If an event is not taken to have occurred, the case is censored at the earliest of the date last traced, the date of first recurrence (if non-null), the date of first distant recurrence (if non-null) and the date of contralateral breast cancer (if non-null).

DIST: DISTANT RECURRENCE

An event is taken to have occurred if:

neither a recurrence nor contralateral breast cancer are reported and death has occurred from 'breast cancer'; or
a distant recurrence is reported and contralateral breast cancer is not reported; or
a date of first distant recurrence exists and the date of contralateral breast cancer exists and is after the date of first distant recurrence.

The event date is taken as the date of first distant recurrence (if any) or else the date died (if dead without recurrence) OR ELSE THE DATE DIED OR LAST TRACED (IF THE DATES OF BOTH FIRST RECURRENCE AND FIRST DISTANT RECURRENCE ARE UNKNOWN).

If an event is not taken to have occurred, the case is censored at the earliest of the date died or last traced, the date of contralateral breast cancer (if non-null) and, if death has occurred from 'unknown' or unstated cause, the date of first recurrence (if non-null).

ENDO: ENDOMETRIAL CANCER MORTALITY

An event is taken to have occurred if:

death has occurred; and
the cause of death is 'other second neoplasm'; and
the death cause text begins '(d. endometrial' or ICD-7 codes 173, 174 or 233, ICD-8 codes 182 or 234 or ICD-9 code 182 are present; and
a recurrence is not reported; and
contralateral breast cancer is not reported.

The event date is taken as the date died.

HEART: CARDIAC MORTALITY

An event is taken to have occurred if:

death has occurred; and
the cause of death is 'heart'; and
a recurrence is not reported; and
contralateral breast cancer is not reported.

The event date is taken as the date died.

LEUK: MORTALITY FROM LYMPHATIC AND HAEMATOPOIETIC CAUSES

An event is taken to have occurred if: death has occurred; and the cause of death is 'lymphatic and haematopoietic'; and a recurrence is not reported; and contralateral breast cancer is not reported. The event date is taken as the date died. If an event is not taken to have occurred, the case is censored at the earliest of the date last traced, the date of first recurrence (if non-null), the date of first distant recurrence (if non-null) and the date of contralateral breast cancer (if non-null).

NONBC: MORTALITY FROM NON-BREAST-CANCER CAUSES WITHOUT RECURRENCE

An event is taken to have occurred if:

death has occurred; and
the cause of death is 'acute treatment toxicity', 'infective', 'lymphatic and haematopoietic', 'other second neoplasm', 'heart', 'thrombotic or embolic', 'other vascular', 'extraneous', 'not 1-8 and not breast cancer' or 'not breast cancer'; and
a recurrence is not reported; and
contralateral breast cancer is not reported.

The event date is taken as the date died.

NONBCUK: MORTALITY FROM UNKNOWN NON-BREAST-CANCER CAUSES

An event is taken to have occurred if: death has occurred; and the cause of death is 'not 1-8 and not breast cancer' or 'not breast cancer'; and a recurrence is not reported; and contralateral breast cancer is not reported. The event date is taken as the date died. If an event is not taken to have occurred, the case is censored at the earliest of the date last traced, the date of first recurrence (if non-null), the date of first distant recurrence (if non-null) and the date of contralateral breast cancer (if non-null).

NONBCVASC: MORTALITY FROM NON-BREAST-CANCER, NON-VASCULAR CAUSES

An event is taken to have occurred if:

death has occurred; and
the cause of death is 'acute treatment toxicity', 'infective', 'lymphatic and haematopoietic', 'other second neoplasm', 'extraneous' or 'not 1-8 and not breast cancer'; and
a recurrence is not reported; and
contralateral breast cancer is not reported.

The event date is taken as the date died.

PP: MORTALITY FROM SECOND PRIMARY CANCER

An event is taken to have occurred if:

death has occurred; and
the cause of death is 'other second neoplasm'; and
a recurrence is not reported; and
contralateral breast cancer is not reported.

The event date is taken as the date died.

RL: RECURRENCE-FREE SURVIVAL

An event is taken to have occurred if:

death has occurred; or
a recurrence is reported; or
contralateral breast cancer is reported.

The event date is taken as the earliest value of the date died (if dead), the date of first recurrence (if non-null) and the date of contralateral breast cancer (if non-null).

If an event is not taken to have occurred, the case is censored at the date last traced.

RLD: DISTANT RECURRENCE AS FIRST EVENT

An event is taken to have occurred if:

neither a recurrence nor contralateral breast cancer are reported and the trial/stratum does not lack recurrence site information and death has occurred from 'breast cancer'; or
A DISTANT RECURRENCE IS REPORTED AND CONTRALATERAL BREAST CANCER IS NOT REPORTED AND THE DATES OF FIRST RECURRENCE AND FIRST DISTANT RECURRENCE ARE BOTH UNKNOWN; OR
dates of first recurrence and first distant recurrence exist and the date of first distant recurrence is on or up to 7 days after the date of first recurrence; and

contralateral breast cancer is not reported; or
contralateral breast cancer is reported after the date of first distant recurrence.

The event date is taken as the date of first distant recurrence (if non-null) or else the date died (if dead from 'breast cancer' without recurrence) OR ELSE THE DATE DIED OR LAST TRACED (IF THE DATES OF FIRST RECURRENCE AND FIRST DISTANT RECURRENCE ARE BOTH UNKNOWN).

If an event is not taken to have occurred, the case is censored at the earliest of the date of first recurrence (if recurrence is present), the date died or last traced and the date of contralateral breast cancer (if non-null).

RLF: RECURRENCE AS FIRST EVENT

An event is taken to have occurred if:

neither a recurrence nor contralateral breast cancer are reported and death has occurred from 'breast cancer'; or
a recurrence is reported; and

contralateral breast cancer is not reported; or
contralateral breast cancer is reported and the date of contralateral breast cancer exists and the date of first recurrence exists and is before the date of contralateral breast cancer.

The event date is taken as the date of first recurrence (if non-null) or else the date died (if dead from 'breast cancer' without recurrence) OR ELSE THE DATE DIED OR LAST TRACED (IF THE DATES OF BOTH FIRST RECURRENCE AND FIRST DISTANT RECURRENCE ARE UNKNOWN).

If an event is not taken to have occurred, the case is censored at the earlier of the date died or last traced and the date of contralateral breast cancer (if non-null).

RLLI: ISOLATED LOCAL RECURRENCE AS FIRST EVENT

An event is taken to have occurred if:

a recurrence is reported and the trial/stratum does not lack recurrence site information; and

contralateral breast cancer is not reported; and

a first distant recurrence is not reported; or
dates of first recurrence and first distant recurrence exist and the date of first distant recurrence is more than 7 days after the date of first recurrence;

or contralateral breast cancer is reported and the dates of contralateral breast cancer and first recurrence exist and the date of first recurrence is before the date of contralateral breast cancer; and

a first distant recurrence is not reported; or
dates of first recurrence and first distant recurrence exist and the date of first distant recurrence is more than 7 days after the date of first recurrence.

The event date is taken as the date of first recurrence.

RLNL: RECURRENCE AS FIRST EVENT OMITTING ISOLATED LOCAL RECURRENCES AS FIRST EVENT

This endpoint is formed by subtraction of the annual events, (O - E) and variance of RLLI from RLF, q.v.

RLU: RECURRENCE AT UNKNOWN SITE AS FIRST EVENT

An event is taken to have occurred if:

neither a recurrence nor contralateral breast cancer are reported and the trial/stratum lacks recurrence site information and death has occurred from 'breast cancer'; or
contralateral breast cancer is not reported; or contralateral breast cancer is reported and the date of contralateral breast cancer exists and the date of first recurrence exists and is before the date of contralateral breast cancer; and a recurrence is reported and the trial/stratum lacks recurrence site information; or LOCAL RECURRENCE IS REPORTED ON A KNOWN DATE AND distant recurrence is reported on an unknown date.

The event date is taken as the date of first recurrence (if non-null) or else the date died (if dead from 'breast cancer' without recurrence).

If an event is not taken to have occurred, the case is censored at the earliest of the date died or last traced, the date of first recurrence (if non-null) and the date of contralateral breast cancer (if non-null).

VASC: VASCULAR MORTALITY

An event is taken to have occurred if:

death has occurred; and
the cause of death is 'heart', 'thrombotic or embolic' or 'other vascular'; and
a recurrence is not reported; and
contralateral breast cancer is not reported.

The event date is taken as the date died.

List of BC 1995 strata

Stratification

Mnemonic

Structure

Unstratified

Entry Age

	Stratum	Abbreviation
1	Entry age less than 50	Age < 50
2	Entry age 50 or more	Age 50+

Entry Age

	Stratum	Abbreviation
1	Entry age less than 40	Age < 40
2	Entry age 40 - 49	Age 40 - 49
3	Entry age 50 - 59	Age 50 - 59
4	Entry age 60 - 69	Age 60 - 69
5	Entry age 70 or more	Age 70+
6	Entry age unknown	Age unknown

Regrouping 8 of Entry Age

-3

	Stratum	Abbreviation
1	Entry age less than 40	Age < 40
2	Entry age 40 - 49	Age 40 - 49
3	Entry age 50 - 59	Age 50 - 59
4	Entry age 60 or more	Age 60+
5	Entry age unknown	Age unknown

Regrouping 29 of Entry Age

-4

	Stratum	Abbreviation
1	Entry age less than 50	Age < 50
2	Entry age 50 - 59	Age 50 - 59
3	Entry age 60 or more	Age 60+
4	Entry age unknown	Age unknown

Regrouping 42 of Entry Age

-5

	Stratum	Abbreviation
1	Entry age less than 50	Age < 50
2	Entry age 50 - 69	Age 50 - 69
3	Entry age 70 or more	Age 70+
4	Entry age unknown	Age unknown

Regrouping 48 of Entry Age

-6

	Stratum	Abbreviation
1	Entry age less than 50	Age < 50
2	Entry age 50 - 59	Age 50 - 59
3	Entry age 60 - 69	Age 60 - 69
4	Entry age 70 or more	Age 70+
5	Entry age unknown	Age unknown

Nodal Status

	Stratum	Abbreviation
1	N0, entry age less than 50	N0 < 50
2	N-, entry age less than 50	N- < 50
3	N1-3, entry age less than 50	N1-3 < 50
4	N4+, entry age less than 50	N4+ < 50
5	'Other' nodal status, entry age less than 50	N+/N? < 50
6	N0, entry age 50 or more	N0 50+
7	N-, entry age 50 or more	N- 50+
8	N1-3, entry age 50 or more	N1-3 50+
9	N4+, entry age 50 or more	N4+ 50+
10	'Other' nodal status, entry age 50 or more	N+/N? 50+

Regrouping 1 of Nodal Status

-1

	Stratum	Abbreviation
1	N0	N0
2	N-	N-
3	N1-3	N1-3
4	N4+	N4+
5	'Other' nodal status	N+/N?

Regrouping 2 of Nodal Status

-2

	Stratum	Abbreviation
1	N0/N-	N0/N-
2	N1-3	N1-3
3	N+/N?	N+/N?
4	N4+	N4+

Regrouping 3 of Nodal Status

-5

	Stratum	Abbreviation
1	N0/N-, entry age less than 50	N0/N- <50
2	N+, entry age less than 50	N+/N? <50
3	N0/N-, entry age 50 or more	N0/N- 50+
4	N+, entry age 50 or more	N+/N? 50+

E.R. Status

	Stratum	Abbreviation
1	ER-poor, entry age less than 50	ERpoor < 50
2	ER unknown, entry age less than 50	ER? < 50
3	ER+, entry age less than 50	ER+ < 50
4	ER++, entry age less than 50	ER++ < 50
5	ER-poor, entry age 50 or more	ERpoor 50+
6	ER unknown, entry age 50 or more	ER? 50+
7	ER+, entry age 50 or more	ER+ 50+
8	ER++, entry age 50 or more	ER++ 50+

Regrouping 4 of E.R. Status

-1

	Stratum	Abbreviation
1	ER-poor	ERpoor
2	ER unknown	ER?
3	ER+	ER+
4	ER++	ER++

Regrouping 5 of E.R. Status

-4

	Stratum	Abbreviation
1	ER-poor, entry age less than 50	ERpoor <50
2	ER unknown, entry age less than 50	ER? <50
3	ER+, entry age less than 50	ER+ <50
4	ER-poor, entry age 50 or more	ERpoor 50+
5	ER unknown, entry age 50 or more	ER? 50+
6	ER+, entry age 50 or more	ER+ 50+

Regrouping 12 of E.R. Status

-2

	Stratum	Abbreviation
1	ER-poor	ERpoor
2	ER unknown	ER?
3	ER+	ER+

Regrouping 14 of E.R. Status

-3

	Stratum	Abbreviation
1	ER-poor, entry age less than 50	ERpoor <50
2	ER+/unknown, entry age less than 50	ER+/? <50
3	ER-poor, entry age 50 or more	ERpoor 50+
4	ER+/unknown, entry age 50 or more	ER+/? 50+

Regrouping 15 of E.R. Status

-3

	Stratum	Abbreviation
1	ER-poor	ERpoor
2	ER+/unknown	ER+/?

P.R. Status

	Stratum	Abbreviation
1	PR-poor, entry age less than 50	PRpoor < 50
2	PR unknown, entry age less than 50	PR? < 50
3	PR+, entry age less than 50	PR+ < 50
4	PR++, entry age less than 50	PR++ < 50
5	PR-poor, entry age 50 or more	PRpoor 50+
6	PR unknown, entry age 50 or more	PR? 50+
7	PR+, entry age 50 or more	PR+ 50+
8	PR++, entry age 50 or more	PR++ 50+

Regrouping 6 of P.R. Status

-1

	Stratum	Abbreviation
1	PR-poor	PRpoor
2	PR unknown	PR?
3	PR+	PR+
4	PR++	PR++

Regrouping 7 of P.R. Status

-4

	Stratum	Abbreviation
1	PR-poor, entry age less than 50	PRpoor <50
2	PR unknown, entry age less than 50	PR? <50
3	PR+, entry age less than 50	PR+ <50
4	PR-poor, entry age 50 or more	PRpoor 50+
5	PR unknown, entry age 50 or more	PR? 50+
6	PR+, entry age 50 or more	PR+ 50+

Regrouping 13 of P.R. Status

-2

	Stratum	Abbreviation
1	PR-poor	PRpoor
2	PR unknown	PR?
3	PR+	PR+

Regrouping 16 of P.R. Status

-3

	Stratum	Abbreviation
1	PR-poor, entry age less than 50	PRpoor <50
2	PR+/unknown, entry age less than 50	PR+/? <50
3	PR-poor, entry age 50 or more	PRpoor 50+
4	PR+/unknown, entry age 50 or more	PR+/? 50+

Regrouping 17 of P.R. Status

-5

	Stratum	Abbreviation
1	PR-poor	PRpoor
2	PR+/unknown	PR+/?

Entry Age and Menop. Status

	Stratum	Abbreviation
1	Pre- and perimenopausal, entry age less than 50	Pre/Peri < 50
2	Postmenopausal, entry age less than 50	Post < 50
3	Pre- and perimenopausal, entry age 50 - 59	Pre/Peri 50-59
4	Postmenopausal, entry age 50 - 59	Post 50-59
5	All menopausal status, entry age 60 - 69	All 60-69
6	All menopausal status, entry age 70 or more	All 70+

Regrouping 31 of Entry Age and Menop. Status

-4

	Stratum	Abbreviation
1	Pre- and perimenopausal, entry age less than 50	Pre/Peri < 50
2	Postmenopausal, entry age less than 50	Post < 50
3	Pre- and perimenopausal, entry age 50 - 59	Pre/Peri 50-59
4	Postmenopausal, entry age 50 - 59	Post 50-59
5	All menopausal status, entry age 60 or more	All 60+

Nodal Status

	Stratum	Abbreviation
1	N0 clearance, entry age less than 50	N0 clear < 50
2	N+ clearance, entry age less than 50	N+ clear < 50
3	N- sampling/clinical, entry age less than 50	N- sam/clin <50
4	N+ sampling/clinical, entry age less than 50	N+ sam/clin <50
5	N unknown, entry age less than 50	N? < 50
6	N0 clearance, entry age 50 or more	N0 clear 50+
7	N+ clearance, entry age 50 or more	N+ clear 50+
8	N- sampling/clinical, entry age 50 or more	N- sam/clin 50+
9	N+ sampling/clinical, entry age 50 or more	N+ sam/clin 50+
10	N unknown, entry age 50 or more	N? 50+

Regrouping 10 of Nodal Status

-1

	Stratum	Abbreviation
1	N0 clearance	N0 clearance
2	N+ clearance	N+ clearance
3	N- sampling/clinical	N- sample/clin.
4	N+ sampling/clinical	N+ sample/clin.
5	N unknown	N unknown

Entry Age and Nodal Status

	Stratum	Abbreviation
1	Entry age less than 40, N0/N-	< 40, N0/N-
2	Entry age 40 - 49, N0/N-	40 - 49, N0/N-
3	Entry age 50 - 59, N0/N-	50 - 59, N0/N-
4	Entry age 60 - 69, N0/N-	60 - 69, N0/N-
5	Entry age 70+, N0/N-	70+, N0/N-
6	Entry age less than 40, N+/N?	< 40, N+/N?
7	Entry age 40 - 49, N+/N?	40 - 49, N+/N?
8	Entry age 50 - 59, N+/N?	50 - 59, N+/N?
9	Entry age 60 - 69, N+/N?	60 - 69, N+/N?
10	Entry age 70+, N+/N?	70+, N+/N?

Regrouping 37 of Entry Age and Nodal Status

-2

	Stratum	Abbreviation
1	Entry age less than 40, N0/N-	< 40, N0/N-
2	Entry age 40 - 49, N0/N-	40 - 49, N0/N-
3	Entry age 50 - 59, N0/N-	50 - 59, N0/N-
4	Entry age 60+, N0/N-	60+, N0/N-
5	Entry age less than 40, N+/N?	< 40, N+/N?
6	Entry age 40 - 49, N+/N?	40 - 49, N+/N?
7	Entry age 50 - 59, N+/N?	50 - 59, N+/N?
8	Entry age 60+, N+/N?	60+, N+/N?

Regrouping 36 of Entry Age and Nodal Status

-3

	Stratum	Abbreviation
1	Entry age less than 50, N0/N-	< 50, N0/N-
2	Entry age 50 - 59, N0/N-	50 - 59, N0/N-
3	Entry age 60 - 69, N0/N-	60 - 69, N0/N-
4	Entry age 70+, N0/N-	70+, N0/N-
5	Entry age less than 50, N+/N?	< 50, N+/N?
6	Entry age 50 - 59, N+/N?	50 - 59, N+/N?
7	Entry age 60 - 69, N+/N?	60 - 69, N+/N?
8	Entry age 70+, N+/N?	70+, N+/N?

Regrouping 30 of Entry Age and Nodal Status

-4

	Stratum	Abbreviation
1	Entry age less than 50, N0/N-	< 50, N0/N-
2	Entry age 50 - 59, N0/N-	50 - 59, N0/N-
3	Entry age 60+, N0/N-	60+, N0/N-
4	Entry age less than 50, N+/N?	< 50, N+/N?
5	Entry age 50 - 59, N+/N?	50 - 59, N+/N?
6	Entry age 60+, N+/N?	60+, N+/N?

Regrouping 11 of Entry Age and Nodal Status

-5

	Stratum	Abbreviation
1	N0/N-	N0/N-
2	N+/N?	N+/N?

Regrouping 39 of Entry Age and Nodal Status

-6

	Stratum	Abbreviation
1	Entry age less than 50, N0/N-	< 50, N0/N-
2	Entry age 50 - 69, N0/N-	50 - 69, N0/N-
3	Entry age 70+, N0/N-	70+, N0/N-
4	Entry age less than 50, N+/N?	< 50, N+/N?
5	Entry age 50 - 69, N+/N?	50 - 69, N+/N?
6	Entry age 70+, N+/N?	70+, N+/N?

Nodal Status (pathological overrides clinical where both available)

	Stratum	Abbreviation
1	N0 clearance, entry age less than 50	N0 clear < 50
2	N+ clearance, entry age less than 50	N+ clear < 50
3	N- sampling/clinical, entry age less than 50	N- sample/clin <50
4	N+ sampling/clinical, entry age less than 50	N+ sample/clin <50
5	N unknown, entry age less than 50	N? < 50
6	N0 clearance, entry age 50 or more	N0 clear 50+
7	N+ clearance, entry age 50 or more	N+ clear 50+
8	N- sampling/clinical, entry age 50 or more	N- sample/clin 50+
9	N+ sampling/clinical, entry age 50 or more	N+ sample/clin 50+
10	N unknown, entry age 50 or more	N? 50+

Regrouping 10 of Nodal Status

-1

	Stratum	Abbreviation
1	N0 clearance	N0 clearance
2	N+ clearance	N+ clearance
3	N- sampling/clinical	N- sample/clin.
4	N+ sampling/clinical	N+ sample/clin.
5	N unknown	N unknown

Nodal Status

	Stratum	Abbreviation
1	N0 clearance	N0 clearance
2	N+ clearance	N+ clearance
3	N- sampling	N- sampling
4	N+ sampling	N+ sampling
5	N- clinical	N- clinical
6	N+ clinical	N+ clinical
7	N- unk. method	N- unk. method
8	N+ unk. method	N+ unk. method
9	N unknown	N unknown

Entry Age and Menop. Status

	Stratum	Abbreviation
1	All menopausal status, entry age less than 40	All < 40
2	Pre- and perimenopausal, entry age 40 - 49	Pre/Peri 40-49
3	Postmenopausal, entry age 40 - 49	Post 40-49
4	Pre- and perimenopausal, entry age 50 - 59	Pre/Peri 50-59
5	Postmenopausal, entry age 50 - 59	Post 50-59
6	All menopausal status, entry age 60 - 69	All 60-69
7	All menopausal status, entry age 70 or more	All 70+

Nodal and E.R. Status

	Stratum	Abbreviation
1	N0/N-, ER-poor, entry age less than 50	N0/N- ERpoor < 50
2	N0/N-, ER unknown, entry age less than 50	N0/N- ER? < 50
3	N0/N-, ER+, entry age less than 50	N0/N- ER+ < 50
4	N+/N?, ER-poor, entry age less than 50	N+/N? ERpoor < 50
5	N+/N?, ER unknown, entry age less than 50	N+/N? ER? < 50
6	N+/N?, ER+, entry age less than 50	N+/N? ER+ < 50
7	N0/N-, ER-poor, entry age 50 or more	N0/N- ERpoor 50+
8	N0/N-, ER unknown, entry age 50 or more	N0/N- ER? 50+
9	N0/N-, ER+, entry age 50 or more	N0/N- ER+ 50+
10	N+/N?, ER-poor, entry age 50 or more	N+/N? ERpoor 50+
11	N+/N?, ER unknown, entry age 50 or more	N+/N? ER? 50+
12	N+/N?, ER+, entry age 50 or more	N+/N? ER+ 50+

Regrouping 24 of Nodal and E.R. Status

-1

	Stratum	Abbreviation
1	N0/N-, ER-poor	N0/N- ERpoor
2	N0/N-, ER unknown	N0/N- ER?
3	N0/N-, ER+	N0/N- ER+
4	N+/N?, ER-poor	N+/N? ERpoor
5	N+/N?, ER unknown	N+/N? ER?
6	N+/N?, ER+	N+/N? ER+

Regrouping 20 of Nodal and E.R. Status

-3

	Stratum	Abbreviation
1	N0/N-, ER-poor, entry age less than 50	N0/N- ERpoor < 50
2	N0/N-, ER+/unknown, entry age less than 50	N0/N- ER+/? < 50
3	N+/N?, ER-poor, entry age less than 50	N+/N? ERpoor < 50
4	N+/N?, ER+/unknown, entry age less than 50	N+/N? ER+/? < 50
5	N0/N-, ER-poor, entry age 50 or more	N0/N- ERpoor 50+
6	N0/N-, ER+/unknown, entry age 50 or more	N0/N- ER+/? 50+
7	N+/N?, ER-poor, entry age 50 or more	N+/N? ERpoor 50+
8	N+/N?, ER+/unknown, entry age 50 or more	N+/N? ER+/? 50+

Regrouping 22 of Nodal and E.R. Status

-5

	Stratum	Abbreviation
1	N0/N-, ER-poor	N0/N- ERpoor
2	N0/N-, ER+/unknown	N0/N- ER+/?
3	N+/N?, ER-poor	N+/N? ERpoor
4	N+/N?, ER+/unknown	N+/N? ER+/?

Nodal and P.R. Status

	Stratum	Abbreviation
1	N0/N-, PR-poor, entry age less than 50	N0/N- PRpoor < 50
2	N0/N-, PR unknown, entry age less than 50	N0/N- PR? < 50
3	N0/N-, PR+, entry age less than 50	N0/N? PR+ < 50
4	N+/N?, PR-poor, entry age less than 50	N+/N? PRpoor < 50
5	N+/N?, PR unknown, entry age less than 50	N+/N? PR? < 50
6	N+/N?, PR+, entry age less than 50	N+/N? PR+ < 50
7	N0/N-, PR-poor, entry age 50 or more	N0/N- PRpoor 50+
8	N0/N-, PR unknown, entry age 50 or more	N0/N- PR? 50+
9	N0/N-, PR+, entry age 50 or more	N0/N- PR+ 50+
10	N+/N?, PR-poor, entry age 50 or more	N+/N? PRpoor 50+
11	N+/N?, PR unknown, entry age 50 or more	N+/N? PR? 50+
12	N+/N?, PR+, entry age 50 or more	N+/N? PR+ 50+

Regrouping 25 of Nodal and P.R. Status

-1

	Stratum	Abbreviation
1	N0/N-, PR-poor	N0/N- PRpoor
2	N0/N-, PR unknown	N0/N- PR?
3	N0/N-, PR+	N0/N? PR+
4	N+/N?, PR-poor	N+/N? PRpoor
5	N+/N?, PR unknown	N+/N? PR?
6	N+/N?, PR+	N+/N? PR+

Regrouping 21 of Nodal and P.R. Status

-3

	Stratum	Abbreviation
1	N0/N-, PR-poor, entry age less than 50	N0/N- PRpoor < 50
2	N0/N-, PR+/unknown, entry age less than 50	N0/N- PR+/? < 50
3	N+/N?, PR-poor, entry age less than 50	N+/N? PRpoor < 50
4	N+/N?, PR+/unknown, entry age less than 50	N+/N? PR+/? < 50
5	N0/N-, PR-poor, entry age 50 or more	N0/N- PRpoor 50+
6	N0/N-, PR+/unknown, entry age 50 or more	N0/N- PR+/? 50+
7	N+/N?, PR-poor, entry age 50 or more	N+/N? PRpoor 50+
8	N+/N?, PR+/unknown, entry age 50 or more	N+/N? PR+/? 50+

Regrouping 23 of Nodal and P.R. Status

-5

	Stratum	Abbreviation
1	N0/N-, PR-poor	N0/N- PRpoor
2	N0/N-, PR+/unknown	N0/N- PR+/?
3	N+/N?, PR-poor	N+/N? PRpoor
4	N+/N?, PR+/unknown	N+/N? PR+/?

Entry Age and E.R. Status

	Stratum	Abbreviation
1	Entry age less than 40, ER-poor	< 40, ERpoor
2	Entry age 40 - 44, ER-poor	40 - 44, ERpoor
3	Entry age 45 - 49, ER-poor	45 - 49, ERpoor
4	Entry age 50 - 54, ER-poor	50 - 54, ERpoor
5	Entry age 55 - 59, ER-poor	55 - 59, ERpoor
6	Entry age 60 - 69, ER-poor	60 - 69, ERpoor
7	Entry age 70 or more, ER-poor	70+, ERpoor
8	Entry age less than 40, ER unknown	< 40, ER?
9	Entry age 40 - 44, ER unknown	40 - 44, ER?
10	Entry age 45 - 49, ER unknown	45 - 49, ER?
11	Entry age 50 - 54, ER unknown	50 - 54, ER?
12	Entry age 55 - 59, ER unknown	55 - 59, ER?
13	Entry age 60 - 69, ER unknown	60 - 69, ER?
14	Entry age 70 or more, ER unknown	70+, ER?
15	Entry age less than 40, ER+	< 40, ER+
16	Entry age 40 - 44, ER+	40 - 44, ER+
17	Entry age 45 - 49, ER+	45 - 49, ER+
18	Entry age 50 - 54, ER+	50 - 54, ER+
19	Entry age 55 - 59, ER+	55 - 59, ER+
20	Entry age 60 - 69, ER+	60 - 69, ER+
21	Entry age 70 or more, ER+	70+, ER+

Regrouping 18 of Entry Age and E.R. Status

-2

	Stratum	Abbreviation
1	Entry age less than 50, ER-poor	< 50, ERpoor
2	Entry age 50 - 59, ER-poor	50 - 59, ERpoor
3	Entry age 60 or more, ER-poor	60+, ERpoor
4	Entry age less than 50, ER unknown	< 50, ER?
5	Entry age 50 - 59, ER unknown	50 - 59, ER?
6	Entry age 60 or more, ER unknown	60+, ER?
7	Entry age less than 50, ER+	< 50, ER+
8	Entry age 50 - 59, ER+	50 - 59, ER+
9	Entry age 60 or more, ER+	60+, ER+

Regrouping 19 of Entry Age and E.R. Status

-3

	Stratum	Abbreviation
1	Entry age less than 40, ER-poor	< 40, ERpoor
2	Entry age 40 - 44, ER-poor	40 - 44, ERpoor
3	Entry age 45 - 49, ER-poor	45 - 49, ERpoor
4	Entry age 50 - 54, ER-poor	50 - 54, ERpoor
5	Entry age 55 - 59, ER-poor	55 - 59, ERpoor
6	Entry age 60 - 69, ER-poor	60 - 69, ERpoor
7	Entry age 70 or more, ER-poor	70+, ERpoor
8	Entry age less than 40, ER+/unknown	< 40, ER+/?
9	Entry age 40 - 44, ER+/unknown	40 - 44, ER+/?
10	Entry age 45 - 49, ER+/unknown	45 - 49, ER+/?
11	Entry age 50 - 54, ER+/unknown	50 - 54, ER+/?
12	Entry age 55 - 59, ER+/unknown	55 - 59, ER+/?
13	Entry age 60 - 69, ER+/unknown	60 - 69, ER+/?
14	Entry age 70 or more, ER+/unknown	70+, ER+/?

Regrouping 32 of Entry Age and E.R. Status

-4

	Stratum	Abbreviation
1	Entry age less than 50, ER-poor	< 50, ERpoor
2	Entry age 50 - 59, ER-poor	50 - 59, ERpoor
3	Entry age 60 - 69, ER-poor	60 - 69, ERpoor
4	Entry age 70 or more, ER-poor	70+, ERpoor
5	Entry age less than 50, ER+/unknown	< 50, ER+/?
6	Entry age 50 - 59, ER+/unknown	50 - 59, ER+/?
7	Entry age 60 - 69, ER+/unknown	60 - 69, ER+/?
8	Entry age 70 or more, ER+/unknown	70+, ER+/?

Regrouping 33 of Entry Age and E.R. Status

-5

	Stratum	Abbreviation
1	Entry age less than 40, ER-poor	< 40, ERpoor
2	Entry age 40 - 49, ER-poor	40 - 49, ERpoor
3	Entry age 50 - 59, ER-poor	50 - 59, ERpoor
4	Entry age 60 - 69, ER-poor	60 - 69, ERpoor
5	Entry age 70 or more, ER-poor	70+, ERpoor
6	Entry age less than 40, ER+/unknown	< 40, ER+/?
7	Entry age 40 - 49, ER+/unknown	40 - 49, ER+/?
8	Entry age 50 - 59, ER+/unknown	50 - 59, ER+/?
9	Entry age 60 - 69, ER+/unknown	60 - 69, ER+/?
10	Entry age 70 or more, ER+/unknown	70+, ER+/?

Regrouping 34 of Entry Age and E.R. Status

-6

	Stratum	Abbreviation
1	Entry age less than 50, ER-poor	< 50, ERpoor
2	Entry age 50 - 59, ER-poor	50 - 59, ERpoor
3	Entry age 60 - 69, ER-poor	60 - 69, ERpoor
4	Entry age 70 or more, ER-poor	70+, ERpoor
5	Entry age less than 50, ER unknown	< 50, ER?
6	Entry age 50 - 59, ER unknown	50 - 59, ER?
7	Entry age 60 - 69, ER unknown	60 - 69, ER?
8	Entry age 70 or more, ER unknown	70+, ER?
9	Entry age less than 50, ER+	< 50, ER+
10	Entry age 50 - 59, ER+	50 - 59, ER+
11	Entry age 60 - 69, ER+	60 - 69, ER+
12	Entry age 70 or more, ER+	70+, ER+

Regrouping 35 of Entry Age and E.R. Status

-7

	Stratum	Abbreviation
1	Entry age less than 40, ER-poor	< 40, ERpoor
2	Entry age 40 - 49, ER-poor	40 - 49, ERpoor
3	Entry age 50 - 59, ER-poor	50 - 59, ERpoor
4	Entry age 60 - 69, ER-poor	60 - 69, ERpoor
5	Entry age 70 or more, ER-poor	70+, ERpoor
6	Entry age less than 40, ER unknown	< 40, ER?
7	Entry age 40 - 49, ER unknown	40 - 49, ER?
8	Entry age 50 - 59, ER unknown	50 - 59, ER?
9	Entry age 60 - 69, ER unknwon	60 - 69, ER?
10	Entry age 70 or more, ER unknown	70+, ER?
11	Entry age less than 40, ER+	< 40, ER+
12	Entry age 40 - 49, ER+	40 - 49, ER+
13	Entry age 50 - 59, ER+	50 - 59, ER+
14	Entry age 60 - 69, ER+	60 - 69, ER+
15	Entry age 70 or more, ER+	70+, ER+

E.R. and P.R. Status

	Stratum	Abbreviation
1	ER-poor, PR-poor, entry age less than 50	ERpoor PRpoor < 50
2	ER-poor, PR unknown, entry age less than 50	ERpoor PR? < 50
3	ER-poor, PR+, entry age less than 50	ERpoor PR+ < 50
4	ER unknown, PR-poor, entry age less than 50	ER? PRpoor < 50
5	ER unknown, PR unknown, entry age less than 50	ER? PR? < 50
6	ER unknown, PR+, entry age less than 50	ER? PR+ < 50
7	ER+, PR-poor, entry age less than 50	ER+ PRpoor < 50
8	ER+, PR unknown, entry age less than 50	ER+ PR? < 50
9	ER+, PR+, entry age less than 50	ER+ PR+ < 50
10	ER-poor, PR-poor, entry age 50 or more	ERpoor PRpoor 50+
11	ER-poor, PR unknown, entry age 50 or more	ERpoor PR? 50+
12	ER-poor, PR+, entry age 50 or more	ERpoor PR+ 50+
13	ER unknown, PR-poor, entry age 50 or more	ER? PRpoor 50+
14	ER unknown, PR unknown, entry age 50 or more	ER? PR? 50+
15	ER unknown, PR+, entry age 50 or more	ER? PR+ 50+
16	ER+, PR-poor, entry age 50 or more	ER+ PRpoor 50+
17	ER+, PR unknown, entry age 50 or more	ER+ PR? 50+
18	ER+, PR+, entry age 50 or more	ER+ PR+ 50+

Regrouping 26 of E.R. and P.R. Status

-1

	Stratum	Abbreviation
1	ER-poor, PR-poor	ERpoor PRpoor
2	ER-poor, PR unknown	ERpoor PR?
3	ER-poor, PR+	ERpoor PR+
4	ER unknown, PR-poor	ER? PRpoor
5	ER unknown, PR unknown	ER? PR?
6	ER unknown, PR+	ER? PR+
7	ER+, PR-poor	ER+ PRpoor
8	ER+, PR unknown	ER+ PR?
9	ER+, PR+	ER+ PR+

Regrouping 27 of E.R. and P.R. Status

-5

	Stratum	Abbreviation
1	ER-poor, PR-poor	ERpoor PRpoor
2	ER-poor, PR+/unknown	ERpoor PR+/?
3	ER+/unknown, PR-poor	ER+/? PRpoor
4	ER+/unknown, PR+/unknown	ER+/? PR+/?

E.R. and Menop. Status

	Stratum	Abbreviation
1	ER-poor, all menopausal status, entry age less than 40	ERpoor < 40
2	ER-poor, pre- and perimenop., entry age 40 - 49	ERpoorPre/Peri 40-49
3	ER-poor, postmenopausal, entry age 40 - 49	ERpoor Post 40-49
4	ER-poor, pre- and perimenop., entry age 50 - 59	ERpoorPre/Peri 50-59
5	ER-poor, postmenopausal, entry age 50 - 59	ERpoor Post 50-59
6	ER-poor, all menopausal status, entry age 60 - 69	ERpoor 60-69
7	ER-poor, all menop. status, entry age 70 or more	ERpoor 70+
8	ER+/unknown, all menop. status, entry less than 40	ER+/? < 40
9	ER+/unkn., pre- and perimenop., entry age 40 - 49	ER+/? Pre/Peri 40-49
10	ER+/unknown, postmenopausal, entry age 40 - 49	ER+/? Post 40-49
11	ER+/unkn., pre- and perimenop., entry age 50 - 59	ER+/? Pre/Peri 50-59
12	ER+/unknown, postmenopausal, entry age 50 - 59	ER+/? Post 50-59
13	ER+/unknown, all menop. status, entry age 60 - 69	ER+/? 60-69
14	ER+/unkn., all menop. status, entry age 70 or more	ER+/? 70+

Entry Age

	Stratum	Abbreviation
1	Entry age less than 40	Age < 40
2	Entry age 40 - 44	Age 40 - 44
3	Entry age 45 - 49	Age 45 - 49
4	Entry age 50 - 54	Age 50 - 54
5	Entry age 55 - 59	Age 55 - 59
6	Entry age 60 - 69	Age 60 - 69
7	Entry age 70 or more	Age 70+
8	Entry age unknown	Age unknown

E.R. and Menop. Status

	Stratum	Abbreviation
1	ER-poor, pre- and peri-, entry age less than 50	ERpoor Pre/Peri < 50
2	ER-poor, postmenopausal, entry age less than 50	ERpoor Post < 50
3	ER-poor, pre- and perimenop., entry age 50 - 59	ERpoorPre/Peri 50-59
4	ER-poor, postmenopausal, entry age 50 - 59	ERpoor Post 50-59
5	ER-poor, all menopausal status, entry age 60 - 69	ERpoor 60-69
6	ER-poor, all menop. status, entry age 70 or more	ERpoor 70+
7	ER+/unkn., pre- and peri-, entry age less than 50	ER+/? Pre/Peri < 50
8	ER+/unknown, postmenop., entry age less than 50	ER+/? Post < 50
9	ER+/unkn., pre- and perimenop., entry age 50 - 59	ER+/? Pre/Peri 50-59
10	ER+/unknown, postmenopausal, entry age 50 - 59	ER+/? Post 50-59
11	ER+/unknown, all menop. status, entry age 60 - 69	ER+/? 60-69
12	ER+/unkn., all menop. status, entry age 70 or more	ER+/? 70+

Nodal Status and Entry Age

	Stratum	Abbreviation
1	N0 clearance, entry age less than 40	N0 clear < 40
2	N+ clearance, entry age less than 40	N+ clear < 40
3	N- sampling/clinical, entry age less than 40	N- sam/clin < 40
4	N+ sampling/clinical, entry age less than 40	N+ sam/clin < 40
5	N unknown, entry age less than 40	N? < 40
6	N0 clearance, entry age 40 - 49	N0 clear 40-49
7	N+ clearance, entry age 40 - 49	N+ clear 40-49
8	N- sampling/clinical, entry age 40 - 49	N- sam/clin 40-49
9	N+ sampling/clinical, entry age 40 - 49	N+ sam/clin 40-49
10	N unknown, entry age 40 - 49	N? 40-49
11	N0 clearance, entry age 50 - 59	N0 clear 50-59
12	N+ clearance, entry age 50 - 59	N+ clear 50-59
13	N- sampling/clinical, entry age 50 - 59	N- sam/clin 50-59
14	N+ sampling/clinical, entry age 50 - 59	N+ sam/clin 50-59
15	N unknown, entry age 50 - 59	N? 50-59
16	N0 clearance, entry age 60 - 69	N0 clear 60-69
17	N+ clearance, entry age 60 - 69	N+ clear 60-69
18	N- sampling/clinical, entry age 60 - 69	N- sam/clin 60-69
19	N+ sampling/clinical, entry age 60 - 69	N+ sam/clin 60-69
20	N unknown, entry age 60 - 69	N? 60-69
21	N0 clearance, entry age 70 or more	N0 clear 70+
22	N+ clearance, entry age 70 or more	N+ clear 70+
23	N- sampling/clinical, entry age 70 or more	N- sam/clin 70+
24	N+ sampling/clinical, entry age 70 or more	N+ sam/clin 70+
25	N unknown, entry age 70 or more	N? 70+
26	N0 clearance, entry age unknown	N0 clear Age ?
27	N+ clearance, entry age unknown	N+ clear Age ?
28	N- sampling/clinical, entry age unknown	N- sam/clin Age ?
29	N+ sampling/clinical, entry age unknown	N+ sam/clin Age ?
30	N unknown, entry age unknown	N? Age ?

Entry Age, Nodal and E.R. Status

ANE

	Stratum	Abbreviation
1	N0/N-, ER-poor, entry age less than 50	N0/N- ERpoor < 50
2	N0/N-, ER unknown, entry age less than 50	N0/N- ER? < 50
3	N0/N-, ER+, entry age less than 50	N0/N- ER+ < 50
4	N+/N?, ER-poor, entry age less than 50	N+/N? ERpoor < 50
5	N+/N?, ER unknown, entry age less than 50	N+/N? ER? < 50
6	N+/N?, ER+, entry age less than 50	N+/N? ER+ < 50
7	N0/N-, ER-poor, entry age 50 - 59	N0/N- ERpoor 50-59
8	N0/N-, ER unknown, entry age 50 - 59	N0/N- ER? 50-59
9	N0/N-, ER+, entry age 50 - 59	N0/N- ER+ 50-59
10	N+/N?, ER-poor, entry age 50 - 59	N+/N? ERpoor 50-59
11	N+/N?, ER unknown, entry age 50 - 59	N+/N? ER? 50-59
12	N+/N?, ER+, entry age 50 - 59	N+/N? ER+ 50-59
13	N0/N-, ER-poor, entry age 60 - 69	N0/N- ERpoor 60-69
14	N0/N-, ER unknown, entry age 60 - 69	N0/N- ER? 60-69
15	N0/N-, ER+, entry age 60 - 69	N0/N- ER+ 60-69
16	N+/N?, ER-poor, entry age 60 - 69	N+/N? ERpoor 60-69
17	N+/N?, ER unknown, entry age 60 - 69	N+/N? ER? 60-69
18	N+/N?, ER+, entry age 60 - 69	N+/N? ER+ 60-69
19	N0/N-, ER-poor, entry age 70 or more	N0/N- ERpoor 70+
20	N0/N-, ER unknown, entry age 70 or more	N0/N- ER? 70+
21	N0/N-, ER+, entry age 70 or more	N0/N- ER+ 70+
22	N+/N?, ER-poor, entry age 70 or more	N+/N? ERpoor 70+
23	N+/N?, ER unknown, entry age 70 or more	N+/N? ER? 70+
24	N+/N?, ER+, entry age 70 or more	N+/N? ER+ 70+

Regrouping 38 of Entry Age, Nodal and E.R. Status

-3

	Stratum	Abbreviation
1	N0/N-, ER-poor, entry age less than 50	N0/N- ERpoor < 50
2	N0/N-, ER+/unknown, entry age less than 50	N0/N- ER+/? < 50
3	N+/N?, ER-poor, entry age less than 50	N+/N? ERpoor < 50
4	N+/N?, ER+/unknown, entry age less than 50	N+/N? ER+/? < 50
5	N0/N-, ER-poor, entry age 50 - 59	N0/N- ERpoor 50-59
6	N0/N-, ER+/unknown, entry age 50 - 59	N0/N- ER+/? 50-59
7	N+/N?, ER-poor, entry age 50 - 59	N+/N? ERpoor 50-59
8	N+/N?, ER+/unknown, entry age 50 - 59	N+/N? ER+/? 50-59
9	N0/N-, ER-poor, entry age 60 - 69	N0/N- ERpoor 60-69
10	N0/N-, ER+/unknown, entry age 60 - 69	N0/N- ER+/? 60-69
11	N+/N?, ER-poor, entry age 60 - 69	N+/N? ERpoor 60-69
12	N+/N?, ER+/unknown, entry age 60 - 69	N+/N? ER+/? 60-69
13	N0/N-, ER-poor, entry age 70 or more	N0/N- ERpoor 70+
14	N0/N-, ER+/unknown, entry age 70 or more	N0/N- ER+/? 70+
15	N+/N?, ER-poor, entry age 70 or more	N+/N? ERpoor 70+
16	N+/N?, ER+/unknown, entry age 70 or more	N+/N? ER+/? 70+

Regrouping 45 of Entry Age, Nodal and E.R. Status

-4

	Stratum	Abbreviation
1	N0/N-, ER-poor, entry age less than 50	N0/N- ERpoor < 50
2	N0/N-, ER+/unknown, entry age less than 50	N0/N- ER+/? < 50
3	N+/N?, ER-poor, entry age less than 50	N+/N? ERpoor < 50
4	N+/N?, ER+/unknown, entry age less than 50	N+/N? ER+/? < 50
5	N0/N-, ER-poor, entry age 50 - 69	N0/N- ERpoor 50-69
6	N0/N-, ER+/unknown, entry age 50 - 69	N0/N- ER+/? 50-69
7	N+/N?, ER-poor, entry age 50 - 69	N+/N? ERpoor 50-69
8	N+/N?, ER+/unknown, entry age 50 - 69	N+/N? ER+/? 50-69
9	N0/N-, ER-poor, entry age 70 or more	N0/N- ERpoor 70+
10	N0/N-, ER+/unknown, entry age 70 or more	N0/N- ER+/? 70+
11	N+/N?, ER-poor, entry age 70 or more	N+/N? ERpoor 70+
12	N+/N?, ER+/unknown, entry age 70 or more	N+/N? ER+/? 70+

Regrouping 46 of Entry Age, Nodal and E.R. Status

-5

	Stratum	Abbreviation
1	N0/N-, ER-poor, entry age less than 50	N0/N- ERpoor < 50
2	N0/N-, ER unknown, entry age less than 50	N0/N- ER? < 50
3	N0/N-, ER+, entry age less than 50	N0/N- ER+ < 50
4	N+/N?, ER-poor, entry age less than 50	N+/N? ERpoor < 50
5	N+/N?, ER unknown, entry age less than 50	N+/N? ER? < 50
6	N+/N?, ER+, entry age less than 50	N+/N? ER+ < 50
7	N0/N-, ER-poor, entry age 50 - 69	N0/N- ERpoor 50-69
8	N0/N-, ER unknown, entry age 50 - 69	N0/N- ER? 50-69
9	N0/N-, ER+, entry age 50 - 69	N0/N- ER+ 50-69
10	N+/N?, ER-poor, entry age 50 - 69	N+/N? ERpoor 50-69
11	N+/N?, ER unknown, entry age 50 - 69	N+/N? ER? 50-69
12	N+/N?, ER+, entry age 50 - 69	N+/N? ER+ 50-69
13	N0/N-, ER-poor, entry age 70 or more	N0/N- ERpoor 70+
14	N0/N-, ER unknown, entry age 70 or more	N0/N- ER? 70+
15	N0/N-, ER+, entry age 70 or more	N0/N- ER+ 70+
16	N+/N?, ER-poor, entry age 70 or more	N+/N? ERpoor 70+
17	N+/N?, ER unknown, entry age 70 or more	N+/N? ER? 70+
18	N+/N?, ER+, entry age 70 or more	N+/N? ER+ 70+

Entry Age and E.R. Status

	Stratum	Abbreviation
1	Entry age less than 50, ER-poor	< 50, ERpoor
2	Entry age 50 - 69, ER-poor	50 - 69, ERpoor
3	Entry age 70 or more, ER-poor	70+, ERpoor
4	Entry age less than 50, ER unknown	< 50, ER?
5	Entry age 50 - 69, ER unknown	50 - 69, ER?
6	Entry age 70 or more, ER unknown	70+, ER?
7	Entry age less than 50, ER+	< 50, ER+
8	Entry age 50 - 69, ER+	50 - 69, ER+
9	Entry age 70 or more, ER+	70+, ER+
10	Entry age less than 50, ER++	< 50, ER++
11	Entry age 50 - 69, ER++	50 - 69, ER++
12	Entry age 70 or more, ER++	70+, ER++

Regrouping 43 of Entry Age and E.R. Status

-2

	Stratum	Abbreviation
1	Entry age less than 50, ER-poor	< 50, ERpoor
2	Entry age 50 - 69, ER-poor	50 - 69, ERpoor
3	Entry age 70 or more, ER-poor	70+, ERpoor
4	Entry age less than 50, ER+/unknown	< 50, ER+/?
5	Entry age 50 - 69, ER+/unknown	50 - 69, ER+/?
6	Entry age 70 or more, ER+/unknown	70+, ER+/?

Regrouping 44 of Entry Age and E.R. Status

-3

	Stratum	Abbreviation
1	Entry age less than 50, ER-poor	< 50, ERpoor
2	Entry age 50 - 69, ER-poor	50 - 69, ERpoor
3	Entry age 70 or more, ER-poor	70+, ERpoor
4	Entry age less than 50, ER unknown	< 50, ER?
5	Entry age 50 - 69, ER unknown	50 - 69, ER?
6	Entry age 70 or more, ER unknown	70+, ER?
7	Entry age less than 50, ER+/ER++	< 50, ER+/++
8	Entry age 50 - 69, ER+/ER++	50 - 69, ER+/++
9	Entry age 70 or more, ER+/ER++	70+, ER+/++

Entry Age and Menop. Status

	Stratum	Abbreviation
1	Pre- and perimenopausal, entry age less than 50	Pre/Peri < 50
2	Postmenopausal, entry age less than 50	Post < 50
3	Pre- and perimenopausal, entry age 50 - 69	Pre/Peri 50-69
4	Postmenopausal, entry age 50 - 69	Post 50-69
5	All menopausal status, entry age 70 or more	All 70+

Entry Age

	Stratum	Abbreviation
1	Entry age less than 30	Age < 30
2	Entry age 30 - 34	Age 30 - 34
3	Entry age 35 - 39	Age 35 - 39
4	Entry age 40 - 44	Age 40 - 44
5	Entry age 45 - 49	Age 45 - 49
6	Entry age 50 - 54	Age 50 - 54
7	Entry age 55 - 59	Age 55 - 59
8	Entry age 60 - 64	Age 60 - 64
9	Entry age 65 - 69	Age 65 - 69
10	Entry age 70 - 74	Age 70 - 74
11	Entry age 75 - 79	Age 75 - 79
12	Entry age 80 or more	Age 80+
13	Entry age unknown	Age unknown

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[End of document, updated to 2 August 2002]