ALLC 1992 - childhood acute lymphoblastic
leukaemia - analysis details: endpoints, steering files and strata
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ALLC
1992 run-time diktats
-
Run-time estimation of unknown randomisation
date
-
Set randomisation date to the earliest known
date of:
-
Today
-
Cutoff date (if any)
-
LFU/death date
-
First-event date
-
Run-time estimation of unknown endpoint/censoring
date
-
Set endpoint/censoring date to the latest
known date of:
-
Randomisation date
-
First-event date date
-
Run-time application of cut-off date, where
relevant
-
If the randomisation date is later than the
cut-off date, omit the case.
-
If the endpoint/censoring date is after the
cut-off date, censor at the cut-off date instead.
-
Run-time estimation of unknown entry age
(except for the age-stratified analysis)
List
of ALLC 1992 endpoints
|
Endpoint |
Mnemonic |
Trial inclusion criteria |
| 1 |
MORTALITY |
DD |
|
ALLC
1992 endpoint definitions (should be read in conjunction with Diktats)
Run-time strategy for data errors
Although efforts are made to create and maintain
an 'error-free' database, numerous minor logical inconsistencies may persist
during correspondence with trialists.
DD: MORTALITY
An event is taken to have occurred if:
The event date is taken as the date died.
If an event is not taken to have occurred,
the case is censored at the date last traced.
List
of ALLC 1992 strata
|
Stratification |
Mnemonic |
Structure |
| 0 |
Unstratified |
0 |
|
| 1 |
Entry Age |
10 |
|
Stratum |
Abbreviation |
| 1 |
Entry age less than 10 |
Age < 10 |
| 2 |
Entry age 10 or more |
Age 10+ |
|
| 2 |
Entry Age |
A |
|
Stratum |
Abbreviation |
| 1 |
Entry age less than 5 |
Age < 5 |
| 2 |
Entry age 5 - 9 |
Age 5 - 9 |
| 3 |
Entry age 10 - 14 |
Age 10 - 14 |
| 4 |
Entry age 15 - 19 |
Age 15 - 19 |
| 5 |
Entry age 20 or more |
Age 20+ |
| 6 |
Entry age unknown |
Age unknown |
|
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[End of document, updated to 3 June 2000]